CEIRS in the News

  • Dr. Gavin Smith’s Research Featured in Reuters

    Dr. Gavin Smith, of St. Jude CEIRS, discussed his recent COVID-19 research at Duke-NUS in Singapore. His group identified a variant of the SARS-CoV-2 virus that causes milder infections compared to the original virus. They found that patients infected with this variant had lower frequency of ICU admittance. Dr. Smith’s group also found that immune... Read more »

  • Dr. Sabra Klein Contributes to Scientific American Piece on COVID-19 Severity

    Dr. Sabra Klein, a member of Johns Hopkins CEIRS, was recently interviewed for a piece published in Scientific American, exploring how and why COVID-19 is more likely to cause severe disease in some people compared to others. The article discusses the biological and social reasons why older people, men, people with chronic conditions, and people... Read more »

  • CEIRS Supports Reagent Development for COVID-19 Seroprevalence Study in Spain

    The CEIRS Network’s response to the COVID-19 pandemic includes generation of resources, reagents, and information for both other members of CEIRS as well as the broader scientific community. Recently, reagents developed by Dr. Florian Krammer at the Icahn School of Medicine at Mount Sinai, part of the Center for Research on Influenza Pathogenesis (CRIP), were... Read more »

Publication Commentaries

  • Study Shows SARS-CoV-2 Can Transmit Through the Air Between Ferrets

    As the COVID-19 pandemic continues, it becomes more important to determine the modes of transmission of the SARS-CoV-2 virus. Understanding whether SARS-CoV-2 can spread through the air will enable public health experts to identify the appropriate control measures to reduce the spread of the outbreak. In a study published in Nature Communications, CEIRS investigators showed that SARS-CoV-2 is transmitted between ferrets through direct contact and via respiratory droplets and aerosols between ferrets.

  • Researchers Investigate Pathogenesis of SARS-CoV-2 in Cynomolgus Macaques

    In a recent report published in Science, CEIRS investigators were part of a group of researchers in the Netherlands that investigated similarities and differences in pathogenesis of COVID-19, MERS, and SARS in cynomolgus macaques (Rockx 2020). Prior to this study, little information on the pathogenesis of SARS-CoV-2 infection was available. Investigators were aiming to characterize the pathogenesis of SARS-CoV-2 infection and compare findings to the pathogenesis of MERS-CoV and SARS-CoV.

  • Researchers Advance the Ferret Model for SARS-CoV-2

    A global team of researchers, including investigators part of the St. Jude Center of Excellence for Influenza Research and Surveillance (SJCEIRS), show in a new study that ferrets are susceptible to the SARS-CoV-2 virus, and that infected ferrets are able to transmit the virus to other ferrets through both direct and indirect contact (Kim 2020). The study, published in Cell Host & Microbe by Young-Il Kim, et al., describes an important new tool in the fight against the global COVID-19 pandemic.

CEIRS COVID-19 Publications

  • SARS-CoV-2 in Quarantined Domestic Cats from COVID-19 Households or Close Contacts, Hong Kong, China

    Barrs VR et al. | Emerging Infectious Diseases | September 16, 2020 | PMID: 32938527
  • Nanotechnology Responses to COVID-19

    Ruiz-Hitzky E et al. | Adv Healthc Mater. | September 3, 2020 | PMID: 32885616
  • Serological identification of SARS-CoV-2 infections among children visiting a hospital during the initial Seattle outbreak

    Dingens AS et al. | Nature Communications | September 1, 2020 | PMID: 32873791
  • Metabolic Syndrome and Viral Pathogenesis: Lessons from Influenza and Coronaviruses

    Smith M et al. | Journal of Virology | August 31, 2020 | PMID: 32661141
  • A High Through-Put Assay For Circulating Antibodies Directed Against The S Protein Of Severe Acute Respiratory Syndrome Coronavirus 2 (Sars-Cov-2)

    Weiss S et al. | J. Infect. Dis. | August 29, 2020 | PMID: 32860510
  • Effects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort study

    Young BE et al. | Lancet | August 18, 2020 | PMID: 32822564
  • Epidemiology, outcomes and associated factors of COVID-19 RT-PCR confirmed cases in the San Pedro Sula Metropolitan Area, Honduras

    Zuniga-Moya JC et al. | Clinical Infectious Diseases | August 17, 2020 | PMID: 32803236
  • Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans

    Arunachalam PS et al. | Science | August 11, 2020 | PMID: 32788292
  • Sex, age, and hospitalization drive antibody responses in a COVID-19 convalescent plasma donor population

    Klein SL et al. | Journal of Clinical Investigation | August 7, 2020 | PMID: 32764200
  • Detection of SARS-CoV-2 by RNAscope in situ hybridization and immunohistochemistry techniques

    Carossino M et al. | Archives of Virology | August 5, 2020 | PMID: 32761270
  • SARS-CoV-2 Virus Culture and Subgenomic RNA for Respiratory Specimens from Patients with Mild Coronavirus Disease

    Perera RAPM et al. | Emerging Infectious Diseases | August 4, 2020 | PMID: 32749957
  • Effect of moist heat reprocessing of N95 respirators on SARS-CoV-2 inactivation and respirator function

    Daeschler SC et al. | Canadian Medical Association Journal | July 30, 2020 | PMID: 32732229
  • A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice

    Laczkó D et al. | Immunity | July 30, 2020 | PMID: 32783919
  • Type I and Type III IFN Restrict SARS-CoV-2 Infection of Human Airway Epithelial Cultures

    Vanderheiden A et al. | Journal of Virology | July 22, 2020 | PMID: 32699094
  • Discovery and Genomic Characterization of a 382-Nucleotide Deletion in ORF7b and ORF8 during the Early Evolution of SARS-CoV-2

    Su YCF et al. | mBio | July 21, 2020 | PMID: 32694143
  • Rapid SARS-CoV-2 whole-genome sequencing and analysis for informed public health decision-making in the Netherlands

    Oude Munnink B et al. | Nature Medicine | July 16, 2020 | PMID: 32678356
  • SARS-CoV-2 is transmitted via contact and via the air between ferrets

    Richard M et al. | Nature Communications | July 8, 2020 | PMID: 32641684
  • COVID-19 in health-care workers in three hospitals in the south of the Netherlands: a cross-sectional study

    Sikkema R et al. | Lancet Infect Dis. | July 2, 2020 | PMID: 32622380
  • The Global Phosphorylation Landscape of SARS-CoV-2 Infection

    Bouhaddou M et al. | Curr Protoc Microbiol. | June 28, 2020 | PMID: 32645325
  • An In Vitro Microneutralization Assay for SARS-CoV-2 Serology and Drug Screening

    Amanat F et al. | Curr Protoc Microbiol. | June 25, 2020 | PMID: 32585083
  • Syrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure development

    Imai M et al. | PNAS | June 22, 2020 | PMID: 32571934
  • COVID-19 in patients with lung cancer

    Luo J et al. | Annals of Oncology | June 17, 2020 | PMID: 32561401
  • A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies

    Hassan AO et al. | Cell | June 10, 2020 | PMID: 32553273
  • The Anticoagulant Nafamostat Potently Inhibits SARS-CoV-2 S Protein-Mediated Fusion in a Cell Fusion Assay System and Viral Infection In Vitro in a Cell-Type-Dependent Manner

    Yamamoto M et al. | Viruses | June 10, 2020 | PMID: 32532094
  • What We Need to Consider During and After the SARS-CoV-2 Pandemic

    Valdivia-Granda WA, Richt JA | Vector Borne Zoonotic Dis. | May 29, 2020 | PMID: 32469633
  • Cross-reactive antibody response between SARS-CoV-2 and SARS-CoV infections

    Lv H et al. | Cell Rep. | May 18, 2020 | PMID: 32426212
  • Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

    Krammer F, Simon V | Science | May 15, 2020 | PMID: 32414781
  • Multivariate analyses of codon usage of SARS-CoV-2 and other betacoronaviruses

    Gu H et al. | Virus Evol. | May 14, 2020 | PMID: 32431949
  • Pathogenesis and transmission of SARS-CoV-2 in golden hamsters

    Sia SF et al. | Nature | May 14, 2020 | PMID: 32408338
  • Infection of dogs with SARS-CoV-2

    Sit THC et al. | Nature | May 14, 2020 | PMID: 32408337
  • Imbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19

    Blanco-Melo et al. | Cell | May 13, 2020 | PMID: 32416070
  • Transmission of SARS-CoV-2 in Domestic Cats

    Halfmann PJ et al. | N. Engl. J. Med. | May 13, 2020 | PMID: 32402157
  • A serological assay to detect SARS-CoV-2 seroconversion in humans

    Amanat F et al. | Nature Medicine | May 12, 2020 | PMID: 32398876
  • Tropism, replication competence, and innate immune responses of the coronavirus SARS-CoV-2 in human respiratory tract and conjunctiva: an analysis in ex-vivo and in-vitro cultures

    Hui KPY et al. | Lancet Respir Med. | May 7, 2020 | PMID: 32386571
  • Stability of SARS-CoV-2 in different environmental conditions

    Chin AWH et al. | Lancet Microbe. | May 1, 2020 | PMID: 32835322
  • Serological assays for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), March 2020

    Perera RA et al. | Euro Surveill. | April 25, 2020 | PMID: 32347204
  • Comparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate model

    Rockx B et al. | Science | April 17, 2020 | PMID: 32303590
  • SARS-CoV-2 Seroconversion in Humans: A Detailed Protocol for a Serological Assay, Antigen Production, and Test Setup

    Stadlbauer D et al. | Curr Protoc Microbiol. | April 17, 2020 | PMID: 32302069
  • SARS-CoV-2 Vaccines: Status Report

    Amanat F, Krammer F | Immunity | April 14, 2020 | PMID: 32259480
  • Infection and Rapid Transmission of SARS-CoV-2 in Ferrets

    Kim YI et al. | Cell Host & Microbe | April 5, 2020 | PMID: 32259477
  • A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV

    Yuan M et al. | Science | April 3, 2020 | PMID: 32245784
  • Gargle lavage as a safe and sensitive alternative to swab samples to diagnose COVID-19: a case report in Japan

    Saito M et al. | Clin. Infect. Dis. | April 2, 2020 | PMID: 32241023
  • Molecular Diagnosis of a Novel Coronavirus (2019-nCoV) Causing an Outbreak of Pneumonia

    Chu DKW et al. | Clin. Chem. | April 1, 2020 | PMID: 32031583
  • Early Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected Pneumonia

    Li Q et al. | N. Engl. J. Med. | March 26, 2020 | PMID: 31995857
  • Identifying SARS-CoV-2 related coronaviruses in Malayan pangolins

    Lam TT et al. | Nature | March, 26, 2020 | PMID: 32218527
  • Public health measures to slow community spread of COVID-19

    Cowling BJ, Aiello A | J. Infect. Dis. | March 20, 2020 | PMID: 32193550
  • Viral dynamics in mild and severe cases of COVID-19

    Liu Y et al. | Lancet Infect Dis. | March 19, 2020 | PMID: 32199493
  • Complete Genome Sequence of a 2019 Novel Coronavirus (SARS-CoV-2) Strain Isolated in Nepal

    Sah R et al. | Microbiol. Resour. Announc. | March 12, 2020 | PMID: 32165386
  • Modified SEIR and AI prediction of the epidemics trend of COVID-19 in China under public health interventions

    Yang Z et al. | J. Thorac. Dis. | March 12, 2020 | PMID: 32274081
  • Viral load of SARS-CoV-2 in clinical samples

    Pan Y et al. | Lancet Infect. Dis. | February 24, 2020 | PMID: 32105638
  • Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR

    Corman VM et al. | Euro Surveill. | January 25, 2020 | PMID: 31992387

CEIRS-Generated Reagents