Dr. Peter Palese Publishes Pre-print Showing Proof-of-concept NDV-based Vaccine for COVID-19

Dr. Peter Palese, Professor at the Icahn School of Medicine at Mount Sinai and member of the Center for Research on Influenza Pathogenesis (CRIP), recently published a pre-print article describing a possible approach to developing a vaccine against SARS-CoV-2. The authors describe a proof-of-concept study where they inserted the immunogenic spike protein from SARS-CoV-2 into the non-pathogenic viral vector Newcastle Disease Virus (NDV). In preliminary tests in mice, mice receiving the vaccine were protected from infection by SARS-CoV-2. NDV is not a human pathogen and the vaccine could easily be produced using embryonated chicken eggs. This is the same system used for producing seasonal influenza vaccines, which means existing vaccine manufacturing capabilities could be extended to produce this vaccine. Though this work has not been peer reviewed, it suggests another possible approach for rapid development of a vaccine for the COVID-19 pandemic.