Dr. Benjamin Miller’s Research Chosen as Editors’ Choice by ACS Publications

Last month, CEIRS member Dr. Benjamin Miller’s article was chosen as Editors’ Choice by ACS Publications. Dr. Miller is a Professor in both the Department of Dermatology and the Department of Biochemistry and Biophysics at the University of Rochester Medical Center School of Medicine and Dentistry, a member of the New York Influenza Center of Excellence (NYICE). Dr. Miller’s team focuses on molecular recognition and biosensing research.

A glycan probe identifying either animal or human influenza strains. (Source: Bioconjugate Chem. 2021)

The article, titled ‘Label-Free, Multiplex Glycan Microarray Biosensor for Influenza Virus Detection’, detailed the development of a novel label-free array to profile the HA segment of influenza viruses. Using this array, the team was able to successfully discriminate between two influenza strains, one human and one avian, using glycan probes that simulate either human or avian cell surface proteins. Historically, four influenza pandemics have originated from animal sources, meaning it is crucial to be able to quickly identify the strains with potential to transmit from animals to humans. Moving forward, the team hopes to develop a wide range of glycan probes analogues to cell surface proteins of various influenza-carrying animals, which would allow the array to be used as a high-throughput method to facilitate global influenza surveillance and rapid pandemic response. Check out the full article here.