CEIRS in the News

  • CRIP Researcher Publishes Collaborative Study on SARS-CoV-2 Variant

    For the last several weeks, the news has been dominated not only by updates on the COVID-19 vaccine but also by a potential mutation in the SARS-CoV-2 virus. There is significant public concern about this variant, which emerged in Europe several months ago and was named D614G, but little research has been published thus far. A recent article in Science Magazine features a collaborative project between University of North Carolina at Chapel Hill and University of Wisconsin-Madison analyzing the effects of the mutation.

  • SJCEIRS Researcher Featured on NPR

    Dr. Stacey Schultz-Cherry, a leading researcher at St. Jude CEIRS, was included in an interview with NPR science correspondent Joe Palca about approval for the Moderna COVID-19 vaccine. The interview focused on the science behind vaccine development and the approval requirements. New COVID-19 vaccines are being approved by the FDA through a process called an “emergency use authorization” in order to get them to vulnerable populations more quickly, so... Read more »

  • CRIP Investigators Publish Key SARS-CoV-2 Seroprevalence Findings

    Several investigators from the Center for Research on Influenza Pathogenesis (CRIP), including Drs. Daniel Stadlbauer, Harm van Bakel, and Florian Krammer, completed a retrospective analysis of SARS-CoV-2 seroprevalence in New York City that has been accepted for publication by Nature. The study is based on a large and demographically diverse dataset that was assessed over several months during the first wave of... Read more »

Publication Commentaries

  • International Collaboration Identifies Biological Markers of COVID-19 Severity

    Most people infected with COVID-19 only have mild or moderate symptoms, but some are much more severe. This study assessed immune response and clinical history from patients at two medical centers in order to compare type and severity of respiratory disease.

  • Hong Kong contact tracing study identifies case clusters and superspreading events

    Previous coronavirus epidemics have included superspreader events as important mechanisms of disease transmission. This study, using data from contact tracing in Hong Kong early in the pandemic, demonstrates how different events and interactions facilitate or prevent SARS-CoV-2 spread.

  • Dutch study does not find evidence of transmission of COVID-19 in hospitals

    A consistent theme throughout the COVID-19 pandemic is assessing risk to healthcare workers. In a study published in The Lancet Infectious Diseases, CEIRS investigators determined that Dutch healthcare workers who were infected in the early stages of the outbreak were likely infected through community spread and not in a hospital setting. Understanding risk of disease spread in hospitals, or nosocomoal transmission, is critical in mitigating future hazards to the population.

CEIRS COVID-19 Publications

February 17, 2021JHCEIRSIdentification of pathogens from the upper respiratory tract of adult emergency department patients at high risk for influenza complications in a pre-Sars-CoV-2 environmentHardick J et al.Diagnostic Microbiology and Infectious Disease33639376
February 16, 2021CRIPQuantifying Absolute Neutralization Titers against SARS-CoV-2 by a Standardized Virus Neutralization Assay Allows for Cross-Cohort Comparisons of COVID-19 SeraOguntuyo KY et al.mBio33593976
February 12, 2021SJCEIRSImpact of the COVID-19 nonpharmaceutical interventions on influenza and other respiratory viral infections in New ZealandHuang QS et al.Nature Communications33579926
February 11, 2021JHCEIRSDurable SARS-CoV-2 B cell immunity after mild or severe diseaseOgega CO et al.Journal of Clinical Investigation33571162
February 11, 2021JHCEIRSAntibody responses to endemic coronaviruses modulate COVID-19 convalescent plasma functionalityMorgenlander WR et al.Journal of Clinical Investigation33571169
February 11, 2021CRIPAntibody titers against SARS-CoV-2 decline, but do not disappear for several monthsYamayoshi S et al.EClinicalMedicine33589882
February 8, 2021NYICECirculating CD4 T cells elicited by endemic coronaviruses display vast disparities in abundance and functional potential linked to both antigen specificity and ageRichards KA et al.Journal of Infectious Diseases33556959
February 3, 2021JHCEIRSHighly multiplexed oligonucleotide probe-ligation testing enables efficient extraction-free SARS-CoV-2 detection and viral genotypingCredle JJ et al.Modern Pathology33536572
February 3, 2021CRIP, Emory-UGA CEIRS, SJCEIRSDevelopment and deployment of COVID-19 vaccines for those most vulnerableKoff WC et al.Science Translational Medicine33536277
February 2, 2021CRIPA replication competent adenovirus-vectored influenza vaccine induces durable systemic and mucosal immunityMatsuda K et al.Journal of Clinical Investigation33529172
January 26, 2021NYICESelection, Identification, and Characterization of SARS-CoV-2 Monoclonal Antibody Resistant MutantsOladunni FS et al.Journal of Virological Methods33513380
January 25, 2021CRIPPlitidepsin has potent preclinical efficacy against SARS-CoV-2 by targeting the host protein eEF1AWhite KM et al.Science33495306
January 19, 2021CRIPSARS-CoV-2 Infection Severity Is Linked to Superior Humoral Immunity against the SpikeGuthmiller JJ et al.mBio33468695
January 19, 2021CRIPSterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein VaccineJangra S et al.Angewandte Chemie33464672
January 12, 2021CRIPMDA5 Governs the Innate Immune Response to SARS-CoV-2 in Lung Epithelial CellsYin X et al.Cell Reports33440148
January 11, 2021CRIPSARS-CoV-2-specific CD8+ T cell responses in convalescent COVID-19 individualsKared H et al.Journal of Clinical Investigation33427749
January 7, 2021CRIPProtective Immunity and Persistent Lung Sequelae in Domestic Cats after SARS-CoV-2 InfectionChiba S et al.Emerging Infectious Diseases33496650
January 6, 2021CRIPImmunological memory to SARS-CoV-2 assessed for up to 8 months after infectionDan JM et al.Science33408181
January 4, 2021CRIPProlonged adaptive immune activation in COVID-19: implications for maintenance of long-term immunity?Mudd PA, Remy KEJournal of Clinical Investigation33104057
January 4, 2021SJCEIRSTropism of SARS-CoV-2, SARS-CoV and influenza virus in canine tissue explantsBui CHT et al.Journal of Infectious Diseases33395484
January 4, 2021SJCEIRSNeutralizing antibody titres in SARS-CoV-2 infectionsLau EHY et al.Nature Communications33397909
December 18, 2020CRIPSARS-CoV-2 D614G variant exhibits efficient replication ex vivo and transmission in vivoHou YJ et al.Science33184236
December 18, 2020CRIPPandemic Vaccines: How Are We Going to Be Better Prepared Next Time?Krammer FMed33521752
December 17, 2020JHCEIRSCOVID-19 Serology at Population Scale: SARS-CoV-2-Specific Antibody Responses in SalivaPisanic N et al.Journal of Clinical Microbiology33067270
December 15, 2020CRIPA household case evidences shorter shedding of SARS-CoV-2 in naturally infected cats compared to their human ownersNeira V et al.Emerging Microbes and Infections33317424
December 11, 2020CRIPAccuracy and stability of saliva as a sample for reverse transcription PCR detection of SARS-CoV-2Uwamino Y et al.Journal of Clinical Pathology32928941
December 10, 2020CRIPComparison of Rapid Antigen Tests for COVID-19Yamayoshi S et al.Viruses33322035
December 10, 2020NYICEPractical considerations for measuring the effective reproductive number, RtGostic KM et al.PLoS Computational Biology33301457
December 9, 2020CRIP, SJCEIRSDistinct inflammatory profiles distinguish COVID-19 from influenza with limited contributions from cytokine stormMudd PA et al.Science Advances33187979
December 4, 2020SJCEIRSFDA-Approved Drugs with Potent In Vitro Antiviral Activity against Severe Acute Respiratory Syndrome Coronavirus 2Mostafa A et al.Pharmaceuticals33291642
December 1, 2020CRIPShedding of Viable SARS-CoV-2 after Immunosuppressive Therapy for CancerAydillo T et al.New England Journal of Medicine33259154
November 26, 2020JHCEIRSCytokine and Chemokine Levels in Coronavirus Disease 2019 Convalescent PlasmaBonny TS et al.Open Forum Infectious Diseases33553467
November 26, 2020CRIPPeripheral immunophenotypes in children with multisystem inflammatory syndrome associated with SARS-CoV-2 infectionCarter MJ et al.Nature Medicine32812012
November 24, 2020SJCEIRSPrevalence of Severe Acute Respiratory Syndrome Coronavirus 2 Neutralizing Antibodies in Egyptian Convalescent Plasma DonorsGomaa MR et al.Frontiers in Microbiology33329484
November 23, 2020Emory-UGA CEIRSIndirect benefits are a crucial consideration when evaluating SARS-CoV-2 vaccine candidatesGallagher ME et al.Nature Medicine33230343
November 21, 2020CRIPNewcastle disease virus (NDV) expressing the spike protein of SARS-CoV-2 as a live virus vaccine candidateSun W et al.EBioMedicine33232870
November 20, 2020CRIPRobust and Specific Secretory IgA Against SARS-CoV-2 Detected in Human MilkFox A et al.iScience33134887
November 19, 2020NYICELeukocyte trafficking to the lungs and beyond: lessons from influenza for COVID-19Alon R et al.Nature Reviews Immunology33214719
November 18, 2020SJCEIRSEGYVIR: An immunomodulatory herbal extract with potent antiviral activity against SARS-CoV-2Roshdy WH et al.PLoS One33206688
November 18, 2020JHCEIRSEvaluation of Serological SARS-CoV-2 Lateral Flow Assays for Rapid Point of Care TestingConklin SE et al.Journal of Clinical Microbiology33208477
November 16, 2020SJCEIRSAntibody Responses to SARS-CoV-2 Antigens in Humans and AnimalsKim H et al.Vaccines33207583
November 5, 2020SJCEIRSDe novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2Linsky TW et al.Science33154107
November 5, 2020CRIPAn ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive SpikeSchoof M et al.Science33154106
November 3, 2020CRIPRepeated cross-sectional sero-monitoring of SARS-CoV-2 in New York CityStadlbauer D et al.Nature33142304
November 2, 2020Emory-UGA CEIRSFull genome viral sequences inform patterns of SARS-CoV-2 spread into and within IsraelMiller D et al.Nature Communications33139704
November 2, 2020JHCEIRSComparative performance of five commercially available serologic assays to detect antibodies to SARS-CoV-2 and identify individuals with high neutralizing titersPatel EU et al.Journal of Clinical Microbiology33139419
October 28, 2020CRIPRobust neutralizing antibodies to SARS-CoV-2 infection persist for monthsWajnberg A et al.Science33115920
October 28, 2020SJCEIRSCommon childhood vaccines do not elicit a cross-reactive antibody response against SARS-CoV-2Kandeil A et al.PloS One33112930
October 27, 2020JHCEIRSRepeat COVID-19 Molecular Testing: Correlation of SARS-CoV-2 Culture with Molecular Assays and Cycle ThresholdsGniazdowski V et al.Clinical Infectious Diseases33104776
October 23, 2020CRIPSARS-CoV-2 Orf6 hijacks Nup98 to block STAT nuclear import and antagonize interferon signalingMiorin L et al.PNAS33097660
October 22, 2020SJCEIRSSerologic Responses in Healthy Adult with SARS-CoV-2 Reinfection, Hong Kong, August 2020Chan PKS et al.Emerging Infectious Diseases33089772
October 21, 2020CRIPEffectiveness of Face Masks in Preventing Airborne Transmission of SARS-CoV-2Ueki H et al.mSphere33087517
October 20, 2020CRIPExperimental infection of domestic dogs and cats with SARS-CoV-2: Pathogenesis, transmission, and response to reexposure in catsBosco-Lauth AM et al.PNAS32994343
October 17, 2020CRIPComparison of Transgenic and Adenovirus hACE2 Mouse Models for SARS-CoV-2 InfectionRathnasinghe R et al.Emerging Microbes and Infections33073694
October 15, 2020CRIPComparative host-coronavirus protein interaction networks reveal pan-viral disease mechanismsGordon DE et al.Science33060197
October 8, 2020CRIP, SJCEIRSSARS-CoV-2 infection, disease and transmission in domestic catsGaudreault NN et al.Emerging Microbes and Infections33028154
October 7, 2020JHCEIRSTargeted Rapid Testing for SARS-CoV-2 in the Emergency Department is Associated with Large Reductions in Uninfected Patient Exposure TimeHinson JS et al.Journal of Hospital Infection33038435
October 2, 2020SJCEIRSSusceptibility of swine cells and domestic pigs to SARS-CoV-2Meekins DA et al.Emerging Microbes and Infections33003988
September 30, 2020CRIPCross-sectional evaluation of humoral responses against SARS-CoV-2 SpikePrévost J et al.Cell Reports Medicine33015650
September 24, 2020CRIPInborn errors of type I IFN immunity in patients with life-threatening COVID-19Zhang Q et al.Science32972995
September 23, 2020CRIPSARS-CoV-2 vaccines in developmentKrammer FNature32967006
September 21, 2020NYICEArray-based analysis of SARS-CoV-2, other coronaviruses, and influenza antibodies in convalescent COVID-19 patientsSteiner DJ et al.Biosensors and Bioelectronics33007615
September 21, 2020CRIPPositive, again! What to make of “re-positive” SARS-CoV-2 molecular test resultsSimon V et al.EBioMedicine32977160
September 18, 2020SJCEIRSIn-Flight Transmission of SARS-CoV-2Choi EM et al.Emerging Infectious Diseases32946370
September 16, 2020SJCEIRSSARS-CoV-2 in Quarantined Domestic Cats from COVID-19 Households or Close Contacts, Hong Kong, ChinaBarrs VR et al.Emerging Infectious Diseases32938527
September 14, 2020CRIPEnterotropism of highly pathogenic avian influenza virus H5N8 from the 2016/2017 epidemic in some wild bird speciesCaliendo V et al.Veterinary Research32928280
September 10, 2020JHCEIRSSARS-CoV-2 Antibody Avidity Responses in COVID-19 Patients and Convalescent Plasma DonorsBenner SE et al.Journal of Infectious Diseases32910175
September 3, 2020CRIPNanotechnology Responses to COVID-19Ruiz-Hitzky E et al.Advanced Healthcare Materials32885616
September 1, 2020CRIPSerological identification of SARS-CoV-2 infections among children visiting a hospital during the initial Seattle outbreakDingens AS et al.Nature Communications32873791
August 31, 2020SJCEIRSMetabolic Syndrome and Viral Pathogenesis: Lessons from Influenza and CoronavirusesSmith M et al.Journal of Virology32661141
August 29, 2020CRIPA High Through-Put Assay For Circulating Antibodies Directed Against The S Protein Of Severe Acute Respiratory Syndrome Coronavirus 2 (Sars-Cov-2)Weiss S et al.Journal of Infectious Diseases32860510
August 26, 2020CRIPRepurposing Fragile X Drugs to Inhibit SARS-CoV-2 Viral ReproductionWestmark CJ et al.Frontiers in Cell and Developmental Biology32984339
August 18, 2020SJCEIRSEffects of a major deletion in the SARS-CoV-2 genome on the severity of infection and the inflammatory response: an observational cohort studyYoung BE et al.The Lancet32822564
August 17, 2020SJCEIRSEpidemiology, outcomes and associated factors of COVID-19 RT-PCR confirmed cases in the San Pedro Sula Metropolitan Area, HondurasZuniga-Moya JC et al.Clinical Infectious Diseases32803236
August 11, 2020SJCEIRSSystems biological assessment of immunity to mild versus severe COVID-19 infection in humansArunachalam PS et al.Science32788292
August 7, 2020JHCEIRSSex, age, and hospitalization drive antibody responses in a COVID-19 convalescent plasma donor populationKlein SL et al.Journal of Clinical Investigation32764200
August 5, 2020SJCEIRSDetection of SARS-CoV-2 by RNAscope in situ hybridization and immunohistochemistry techniquesCarossino M et al.Archives of Virology32761270
August 4, 2020SJCEIRSSARS-CoV-2 Virus Culture and Subgenomic RNA for Respiratory Specimens from Patients with Mild Coronavirus DiseasePerera RAPM et al.Emerging Infectious Diseases32749957
July 30, 2020CRIPA Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in MiceLaczkó D et al.Immunity32783919
July 30, 2020SJCEIRSEffect of moist heat reprocessing of N95 respirators on SARS-CoV-2 inactivation and respirator functionDaeschler SC et al.Canadian Medical Association Journal32732229
July 24, 2020CRIPDiscovery of SARS-CoV-2 antiviral drugs through large-scale compound repurposingRiva L et al.Nature32707573
July 22, 2020Emory-UGA CEIRSType I and Type III IFN Restrict SARS-CoV-2 Infection of Human Airway Epithelial CulturesVanderheiden A et al.Journal of Virology32699094
July 21, 2020SJCEIRSDiscovery and Genomic Characterization of a 382-Nucleotide Deletion in ORF7b and ORF8 during the Early Evolution of SARS-CoV-2Su YCF et al.mBio32694143
July 17, 2020CRIPIntroductions and early spread of SARS-CoV-2 in the New York City areaGonzalez-Reiche AS et al.Science32471856
July 16, 2020CRIPRapid SARS-CoV-2 whole-genome sequencing and analysis for informed public health decision-making in the NetherlandsOude Munnink B et al.Nature Medicine32678356
July 8, 2020CRIPSARS-CoV-2 is transmitted via contact and via the air between ferretsRichard M et alNature Communications32641684
July 2, 2020CRIPCOVID-19 in health-care workers in three hospitals in the south of the Netherlands: a cross-sectional studySikkema R et al.The Lancet Infectious Diseases32622380
June 28, 2020CRIPThe Global Phosphorylation Landscape of SARS-CoV-2 InfectionBouhaddou M et al.Current Protocols in Microbiology32645325
June 25, 2020CRIPAn In Vitro Microneutralization Assay for SARS-CoV-2 Serology and Drug ScreeningAmanat F et al.Current Protocols in Microbiology32585083
June 22, 2020CRIPSyrian hamsters as a small animal model for SARS-CoV-2 infection and countermeasure developmentImai M et al.PNAS32571934
June 17, 2020CRIPCOVID-19 in patients with lung cancerLuo J et al.Annals of Oncology32561401
June 10, 2020CRIPThe Anticoagulant Nafamostat Potently Inhibits SARS-CoV-2 S Protein-Mediated Fusion in a Cell Fusion Assay System and Viral Infection In Vitro in a Cell-Type-Dependent MannerYamamoto M et al.Viruses32532094
June 10, 2020CRIPA SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing AntibodiesHassan AO et al.Cell32553273
May 29, 2020SJCEIRSWhat We Need to Consider During and After the SARS-CoV-2 PandemicValdivia-Granda WA, Richt JAVector-Borne Zoonotic Diseases32469633
May 18, 2020SJCEIRSCross-reactive antibody response between SARS-CoV-2 and SARS-CoV infectionsLv H et al.Cell Reports32426212
May 15, 2020CRIPSerology assays to manage COVID-19Krammer F, Simon VScience32414781
May 14, 2020SJCEIRSInfection of dogs with SARS-CoV-2Sit THC et al.Nature32408337
May 14, 2020SJCEIRSPathogenesis and transmission of SARS-CoV-2 in golden hamstersSia SF et al.Nature32408338
May 14, 2020SJCEIRSMultivariate analyses of codon usage of SARS-CoV-2 and other betacoronavirusesGu H et al.Virus Evolution32431949
May 13, 2020CRIPTransmission of SARS-CoV-2 in Domestic CatsHalfmann PJ et al.New England Journal of Medicine32402157
May 13, 2020CRIPImbalanced Host Response to SARS-CoV-2 Drives Development of COVID-19Blanco-Melo et al.Cell32416070
May 12, 2020CRIPA serological assay to detect SARS-CoV-2 seroconversion in humansAmanat F et al.Nature Medicine32398876
May 8, 2020CRIPSymptom Profiles and Risk Factors for Hospitalization in Patients With SARS-CoV-2 and COVID-19: A Large Cohort From South AmericaDíaz LA et al.Gastroenterology32437750
May 7, 2020SJCEIRSTropism, replication competence, and innate immune responses of the coronavirus SARS-CoV-2 in human respiratory tract and conjunctiva: an analysis in ex-vivo and in-vitro culturesHui KPY et al.The Lancet Respiratory Medicine32386571
May 1, 2020SJCEIRSStability of SARS-CoV-2 in different environmental conditionsChin AWH et al.The Lancet Microbe32835322
April 30, 2020CRIPA SARS-CoV-2 protein interaction map reveals targets for drug repurposingGordon DE et al.Nature32353859
April 25, 2020SJCEIRSSerological assays for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), March 2020Perera RA et al.Eurosurveillance32347204
April 17, 2020CRIPSARS-CoV-2 Seroconversion in Humans: A Detailed Protocol for a Serological Assay, Antigen Production, and Test SetupStadlbauer D et al.Current Protocols in Microbiology32302069
April 17, 2020CRIPComparative pathogenesis of COVID-19, MERS, and SARS in a nonhuman primate modelRockx B et al.Science32303590
April 14, 2020CRIPSARS-CoV-2 Vaccines: Status ReportAmanat F, Krammer FImmunity32259480
April 5, 2020SJCEIRSInfection and Rapid Transmission of SARS-CoV-2 in FerretsKim YI et al.Cell Host & Microbe32259477
April 3, 2020SJCEIRSA highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoVYuan M et al.Science32245784
April 2, 2020CRIPGargle lavage as a safe and sensitive alternative to swab samples to diagnose COVID-19: a case report in JapanSaito M et al.Clinical Infectious Diseases32241023
April 1, 2020SJCEIRSMolecular Diagnosis of a Novel Coronavirus (2019-nCoV) Causing an Outbreak of PneumoniaChu DKW et al.Clinical Chemistry32031583
March 26, 2020SJCEIRSIdentifying SARS-CoV-2 related coronaviruses in Malayan pangolinsLam TT et al.Nature32218527
March 26, 2020SJCEIRSEarly Transmission Dynamics in Wuhan, China, of Novel Coronavirus-Infected PneumoniaLi Q et al.New England Journal of Medicine31995857
March 20, 2020SJCEIRSPublic health measures to slow community spread of COVID-19Cowling BJ, Aiello AJournal of Infectious Diseases32193550
March 19, 2020SJCEIRSViral dynamics in mild and severe cases of COVID-19Liu Y et al.The Lancet Infectious Diseases32199493
March 12, 2020SJCEIRSModified SEIR and AI prediction of the epidemics trend of COVID-19 in China under public health interventionsYang Z et al.Journal of Thoracic Disease32274081
March 12, 2020SJCEIRSComplete Genome Sequence of a 2019 Novel Coronavirus (SARS-CoV-2) Strain Isolated in NepalSah R et al.Microbiology Resource Announcements32165386
February 24, 2020SJCEIRSViral load of SARS-CoV-2 in clinical samplesPan Y et al.The Lancet Infectious Diseases32105638
January 25, 2020SJCEIRSDetection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCRCorman VM et al.Eurosurveillance31992387

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