While many biological variables—age, immune status, pregnancy, and infection history—are considered in the formulation and evaluation of influenza vaccines, sex rarely makes the list. The Women’s Health Seminar Series by the NIH Office of Research on Women’s Health (ORWH) featured Dr. Sabra Klein (JHCEIRS) and her research on, “Sex Differences in Vaccine Efficacy.” The video highlights how sex affects the immune response to influenza vaccines and lasting vaccine-induced immunity. She describes critical considerations for improving vaccine development, dosage, and administration.
From Dr. Klein about the impact of this work:
“Data from these studies and others should provide rationale for disaggregation and analysis of human clinical vaccine studies based on the sex/gender of the vaccinees. Sex differences in vaccine efficacy suggest that consideration should be given to sex-specific vaccine formulations, doses, and routes of administration. The ultimate goal of vaccines is to protect all individuals equally, which may require treating males and female differently.”
Watch this VideoCast courtesy of the NIH Office of Research on Women’s Health (ORWH).