Several investigators from the Center for Research on Influenza Pathogenesis (CRIP), including Drs. Daniel Stadlbauer, Harm van Bakel, and Florian Krammer, completed a retrospective analysis of SARS-CoV-2 seroprevalence in New York City that has been accepted for publication by Nature. The study is based on a large and demographically diverse dataset that was assessed over several months during the first wave of COVID-19 infections. Surveillance data reveal that SARS-CoV-2 was circulating in the city as early as mid-February and an estimated 20% of its population have already been infected. Despite optimism surrounding vaccine development, the COVID-19 pandemic is still a major concern worldwide. Analyses like this will continue to shape scientific understanding of disease dynamics, which is especially valuable as cases spike secondary to holiday gatherings and colder weather.