Researchers Investigate Pathogenesis of SARS-CoV-2 in Cynomolgus Macaques

In a recent report published in Science, CEIRS investigators were part of a group of researchers in the Netherlands that investigated similarities and differences in pathogenesis of COVID-19, MERS, and SARS in cynomolgus macaques (Rockx 2020). Prior to this study, little information on the pathogenesis of SARS-CoV-2 infection was available. Investigators were aiming to characterize the pathogenesis of SARS-CoV-2 infection and compare findings to the pathogenesis of MERS-CoV and SARS-CoV.

FDA Authorizes Emergency Use of Dr. Florian Krammer’s COVID-19 Antibody Test

Last week, the FDA issued their authorization for emergency use of a SARS-CoV-2 antibody test developed by Dr. Florian Krammer’s microbiology lab for in vitro diagnosis of COVID-19 cases. Dr. Krammer, an investigator at CEIRS Center for Research on Influenza Pathogenesis (CRIP), started developing the test in January 2020. The ELISA test detects the presence… Read more »

Dr. David Topham Discusses COVID-19 Antibody Testing on TODAY

Dr. David Topham, Principal Investigator at the New York Influenza Center of Excellence (NYICE), was interviewed by NBC’s TODAY as part of an article on the process of coronavirus antibody testing. Antibody tests can be used to determine if a person had a past coronavirus infection. TODAY notes that while more than 150 antibody tests… Read more »

Dr. Andrew Pekosz Talks COVID-19 on Bloomberg Radio

The Bloomberg Daybreak Radio Show covers a range of business, economic, and market news between local and global levels. Now on Wednesday and Friday mornings, listeners can tune in for scientific discussion as well. Dr. Andrew Pekosz, co-Principal Investigator of the JHCEIRS Center and a Professor of Molecular Microbiology and Immunology at the Johns Hopkins… Read more »

Dr. Florian Krammer Develops Antibody Test for COVID-19

Dr. Florian Krammer, a Professor at the Icahn School of Medicine at Mount Sinai and part of the Center for Research on Influenza Pathogenesis (CRIP), talks about efforts to develop one of the first antibody-based tests for SARS-CoV-2 infections. Some patients may exhibit few, if any, symptoms of COVID-19, proving these tests to be important to determine whether people have been infected with COVID-19.

Sequencing COVID-19 Clinical Samples with CEIRS Investigators

Investigators Peter Thielen and Tom Mehoke, from Johns Hopkins University Applied Physics Laboratory, part of the JHCEIRS Center, discuss their efforts toward sequencing the SARS-CoV-2 virus from clinical samples. Their use of the MinION handheld sequencers and protocol optimization advances will allow them to deploy these units at point-of-care settings to deliver same-day sequencing results.

Researchers Advance the Ferret Model for SARS-CoV-2

A global team of researchers, including investigators part of the St. Jude Center of Excellence for Influenza Research and Surveillance (SJCEIRS), show in a new study that ferrets are susceptible to the SARS-CoV-2 virus, and that infected ferrets are able to transmit the virus to other ferrets through both direct and indirect contact (Kim 2020). The study, published in Cell Host & Microbe by Young-Il Kim, et al., describes an important new tool in the fight against the global COVID-19 pandemic.